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Volume 13 · Number 1 · Pages 147–149
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Function vs. Structure: The Immune System as a Case in Point

Jorge Mpodozis

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Abstract

Open peer commentary on the article “The Epigenetic Immune Network” by Nelson Monteiro Vaz & Luiz Antônio Botelho Andrade. Upshot: Functional approaches to systems, while of heuristic value in many cases, may lead to a neglect of some fundamental aspects of systemic phenomenology. The adoption of an alternative structural/mechanistic approach can be very enlightening to unveil, and effective to solve, the conceptual and heuristic limitations resulting from the adoption of the functional approach. The epistemic history of immunology, as described in the target article, offers compelling evidences of this situation.

Citation

Mpodozis J. (2017) Function vs. Structure: The immune system as a case in point. Constructivist Foundations 13(1): 147–149. http://constructivist.info/13/1/147

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References

Carvalho C. R., Lenzi H. L., Correa-Oliveira R. & Vaz N. M. (2002) Indirect effects of oral tolerance to ovalbumin interfere with the immune responses triggered by Schistosoma mansoni eggs. Brazilian Journal of Medical and Biological Research 35(10): 1195–1199. ▸︎ Google︎ Scholar
Costa R. A., Ruiz-de-Souza V., Azevedo Jr. G. M., Gava E., Kitten G. T., Vaz N. M. & Carvalho C. R. (2011) Indirect effects of oral tolerance improve wound healing in skin. Wound Repair and Regeneration 19(4): 487–497. ▸︎ Google︎ Scholar
Haury M., Sundblad A., Grandien A., Barreau C., Coutinho A. & Nobrega A. (1997) The repertoire of serum IgM in normal mice is largely independent of external antigenic contact. European Journal of Immunology 27(6): 1557–1563. ▸︎ Google︎ Scholar
Maturana H. R. (1985) Comment by Humberto R. Maturana: The mind is not in the head. Journal of Social and Biological Structures 8(4): 308–311. http://cepa.info/575
Maturana H. R., Mpodozis J. & Letelier J. C. (1995) Brain, language and the origin of human mental functions. Biological Research 28(1): 15–26. ▸︎ Google︎ Scholar
Vaz N., Faria A. M. C., Verdolin B. A. & Carvalho C. R. (1997) Immaturity, ageing and oral tolerance. Scandinavian Journal of Immunology 46(3): 225–229. ▸︎ Google︎ Scholar
Verdolin B. A., Ficker S. M., Faria A. M. C., Vaz N. M. & Carvalho C. R. (2001) Stabilization of serum antibody responses triggered by initial mucosal contact with the antigen independently of oral tolerance induction. Brazilian Journal of Medical and Biological Research 34(2): 211–219. ▸︎ Google︎ Scholar

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