Paradigmatic Shift in Immunology: Implications for Medicine, Pathophysiology and Public Health Policies
Vitor Pordeus
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Abstract
Open peer commentary on the article “Maturanian Observer-Dependent Immunology” by Nelson Monteiro Vaz. Abstract: I comment on the scientific contributions of the immunologist, Nelson Monteiro Vaz, with whom I have been working over the last 20 years. Inspired by the work of Maturana, Vaz has spent 50 years in an ongoing research effort towards what can be considered a paradigm shift in immunology. This has repercussions on how we understand physiology and pathophysiology, nutrition and diet, the microbiome and the very way we explain health and disease. The paradigmatic change is grounded in Maturana’s biology of cognition and evolution through natural drift, and demonstrates the wide-reaching implications of the premises under which we do science by noting how these have consequences for public health and medical disease theories.
Citation
Pordeus V. (2022) Paradigmatic shift in immunology: Implications for medicine, pathophysiology and public health policies. Constructivist Foundations 18(1): 078–081. https://constructivist.info/18/1/078
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Cantaruti T. A., Costa R. A., de Souza K. S., Vaz N. M. & Carvalho C. R. (2017) Indirect effects of immunological tolerance to a regular dietary protein reduce cutaneous scar formation. Immunology 151(3): 314–323.
▸︎ Google︎ Scholar
Cantaruti T. A., Costa R. A., Franco-Valencia K., Nóbrega I. B. C., de Almeida Galdino D. A., Vaz N. M. & Carvalho C. R. (2019) Parenteral re-exposure to an immunologically tolerated protein up to 6h after skin injuries improves wound healing in diabetic mice. Journal of Immunology and Regenerative Medicine 6: 100022.
▸︎ Google︎ Scholar
Costa R. A., Matos L. B. O., Cantaruti T. A., de Souza K. S., Vaz N. M. & Carvalho C. R. (2016) Systemic effects of oral tolerance reduce the cutaneous scarring. Immunobiology 221(3): 475–485.
▸︎ Google︎ Scholar
Costa R. A., Ruiz‐de‐Souza V., Azevedo Jr G. M., Gava E., Kitten G. T., Vaz N. M. & Carvalho C. R. (2011) Indirect effects of oral tolerance improve wound healing in skin. Wound Repair and Regeneration 19(4): 487–497.
▸︎ Google︎ Scholar
da Silva Menezes J., de Sousa Mucida D., Cara D. C., Alvarez‐Leite J. I., Russo M., Vaz N. M. & de Faria A. M. C. (2003) Stimulation by food proteins plays a critical role in the maturation of the immune system. International immunology 15(3): 447–455.
▸︎ Google︎ Scholar
Faria A. M. & Weiner H. L. (1999) Oral tolerance: Mechanisms and therapeutic applications. Advances in immunology 73: 153–264.
▸︎ Google︎ Scholar
Faria A. M., Garcia G., Rios M. J., Michalaros C. L. & Vaz N. M. (1993) Decrease in susceptibility to oral tolerance induction and occurrence of oral immunization to ovalbumin in 20–38-week-old mice: The effect of interval between oral exposures and rate of antigen intake in the oral immunization. Immunology 78(1): 147– 151.
▸︎ Google︎ Scholar
Franco-Valencia K., Nóbrega I. B. C., Cantaruti T., Barra A., Klein A., Azevedo-Jr G. M., Costa R. A. & Carvalho C. R. (2022) Subcutaneous injection of an immunologically tolerated protein up to 5 days before skin injuries improves wound healing. Brazilian Journal of Medical and Biological Research 55.
▸︎ Google︎ Scholar
Freire P. (1970) Cultural action for freedom. Harvard Educational Review, Cambridge MA.
▸︎ Google︎ Scholar
Freire P. (2021) Pedagogy of hope: Reliving pedagogy of the oppressed. Bloomsbury Publishing, London.
▸︎ Google︎ Scholar
Hossain Z., Reza A. H. M., Qasem W. A., Friel J. K. & Omri A. (2022) Development of the immune system in the human embryo. Pediatric Research 92: 951–955.
▸︎ Google︎ Scholar
Jung C. G. (1931) Problems of modern psychotherapy. Schweizerische Medizinische Wochenschrift: 810–16.
▸︎ Google︎ Scholar
Lemke H., Coutinho A. & Lange H. (2004) Lamarckian inheritance by somatically acquired maternal IgG phenotypes. Trends in Immunology 25(4): 180–186.
▸︎ Google︎ Scholar
Maron R., Sukhova G., Faria A. M., Hoffmann E., Mach F., Libby P. & Weiner H. L. (2002) Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 106(13): 1708–1715.
▸︎ Google︎ Scholar
Nunes-Silva V., Frantz S. & Ramos G. C. (2017) Lymphocytes at the heart of wound healing. The Immunology of Cardiovascular Homeostasis and Pathology: 225–250.
▸︎ Google︎ Scholar
Pordeus V. (2014) Restoring the art of healing: A transcultural psychiatry case report. Journal of Psychology and Psychotherapy Research 1(2): 47–49.
▸︎ Google︎ Scholar
Pordeus V. (2018) Restoring the art of healing: Biology of cognition, cultural psychiatry and theater as public policy of mental health promotion. Université Populaire d’Art et Science, Montreal.
▸︎ Google︎ Scholar
Ramos G. C., Dalbó S., Leite D. P., Goldfeder E., Carvalho C. R., Vaz N. M. & Assreuy J. (2012) The autoimmune nature of post-infarct myocardial healing: Oral tolerance to cardiac antigens as a novel strategy to improve cardiac healing. Autoimmunity 45(3): 233–244.
▸︎ Google︎ Scholar
Richman L. K., Chiller J. M., Brown W. R., Hanson D. G. & Vaz N. M. (1978) Enterically induced immunologic tolerance: I. Induction of suppressor T lymphocytes by intragastric administration of soluble proteins. The Journal of Immunology 121(6): 2429–2434.
▸︎ Google︎ Scholar
Rooks C., Veledar E., Goldberg J., Bremner J. D. & Vaccarino V. (2012) Early trauma and inflammation: Role of familial factors in a study of twins. Psychosomatic Medicine 74(2):146–152.
▸︎ Google︎ Scholar
Thursby E. & Juge N. (2017) Introduction to the human gut microbiota. Biochemical journal 474(11): 1823–1836.
▸︎ Google︎ Scholar
Vaz N. M., De Faria A. M. C., Verdolin B. A., Silva Neto A. F., Menezes J. S. & Carvalho C. R. (2003) The conservative physiology of the immune system. Brazilian Journal of Medical and Biological Research 36: 13–22.
▸︎ Google︎ Scholar
Walker W. A. (2017) The importance of appropriate initial bacterial colonization of the intestine in newborn, child, and adult health. Pediatric Research 82(3): 387–395.
▸︎ Google︎ Scholar
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