Volume 18 · Number 1 · Pages 078–081
Paradigmatic Shift in Immunology: Implications for Medicine, Pathophysiology and Public Health Policies

Vitor Pordeus

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Open peer commentary on the article “Maturanian Observer-Dependent Immunology” by Nelson Monteiro Vaz. Abstract: I comment on the scientific contributions of the immunologist, Nelson Monteiro Vaz, with whom I have been working over the last 20 years. Inspired by the work of Maturana, Vaz has spent 50 years in an ongoing research effort towards what can be considered a paradigm shift in immunology. This has repercussions on how we understand physiology and pathophysiology, nutrition and diet, the microbiome and the very way we explain health and disease. The paradigmatic change is grounded in Maturana’s biology of cognition and evolution through natural drift, and demonstrates the wide-reaching implications of the premises under which we do science by noting how these have consequences for public health and medical disease theories.


Pordeus V. (2022) Paradigmatic shift in immunology: Implications for medicine, pathophysiology and public health policies. Constructivist Foundations 18(1): 078–081. https://constructivist.info/18/1/078

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