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Summary: Based on the book, the overall impression is that systems biology struggles with the limits of first-order cybernetics and tries to overcome it by mixing bottom up and top down methods from classical approaches such as genetics, molecular biology and enzymology. However, the contributors avoid the step from first-order to second-order cybernetics.
Goorhuis H. (2007) Towards a constructivist systems biology? Review of: F. C. Boogerd et al. (eds.) (2006) systems biology. Constructivist Foundations 3(1): 57. http://constructivist.info/3/1/057
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